Dehydroepiandrosterone in systemic lupus erythematosus: relationship between dosage, serum levels, and clinical response. J Rheumatol.
Baulieu EE. Thomas G, Legrain S, et al. Dehydroepiandrosterone treatment effects on weight, bone density, bone metabolism and mood in women suffering from anorexia nervosa - a pilot study. Psychiatry Res. The Andro Project: Physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program.
Arch Intern Med. Corrigan AB. Dehydroepiandrosterone and sport. Med J Aust. Blood and tissue dehydroepiandrosterone sulphate levels and their relationship to chronic inflammatory bowel disease.
Clin Exp Rheumatol. An open-label dose-escalation trial of oral dehydroepiandrosterone tolerance and pharmacokinetics in patients with HIV disease. J Acquir Immune Defic Syndr.
A randomized controlled trial of dehydroepiandrosterone in postmenopausal women with fibromyalgia. Dehydroepiandrosterone replacement in aging humans. J Clin Endocrinol Metabol. Oral dehydroepiandrosterone supplementation modulates spontaneous and growth hormone-releasing hormone-induced growth hormone and insulin-like growth factor-1 secretion in early and late postmenopausal women. Differential effect of oral dehydroepiandrosterone-sulfate on metabolic syndrome features in pre- and postmenopausal obese women.
Clin Endocrinol Oxf. Changes in bone turnover markers and menstrual function after short-term oral DHEA in young women with anorexia nervosa. J Bone Miner Res.
Dehydroepiandrosterone DHEA supplementation for cognitive function in healthy elderly people. Cochrane Database Syst Rev. DHEA protects against visceral obesity and muscle insulin resistance in rats fed a high-fat diet. Am J Physiol. DHEA deficiency syndrome: a new term for old age? J Endocrinol. Chemotherapy of murine colorectal carcinoma with cisplatin and cisplatin plus 3'- deoxy-3'- azidothymidine. Anticancer Res. Ingestion of a dietary supplement containing dehydroepiandrosterone DHEA and androstenedione has minimal effect on immune function in middle-aged men.
J Am Coll Nutr. J Affect Disord. Labrie F. DHEA as physiological replacement therapy at menopause. J Endocrinol Invest. Effect of month dehydroepiandrosterone replacement therapy on bone, vagina, and endometrium in postmenopausal women.
Legrain S, Girard L. Pharmacology and therapeutic effects of dehydroepiandrosterone in older subjects. Drugs Aging. Effects of dehydroepiandrosterone DHEA supplementation on hormonal, metabolic and behavioral status in patients with hypoadrenalism. Dehydroepiandrosterone enhances the hypnotic and hypothermic effects of ethanol and pentobarbital. Pharmacol Biochem Behav. Synergistic interaction between dehydroepiandrosterone and prednisolone in the inhibition of rat lymphocyte proliferation.
Immunopharmacol Immunotoxicol. The relationship between longitudinal declines in dehydroepiandrosterone sulfate concentrations and cognitive performance in older men. The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women. Efficacy of dehydroepiandrosterone to improve ovarian response in women with diminished ovarian reserve: a meta-analysis.
Reprod Biol Endocrinol. Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat bud does not alter insulin sensitivity in normal men. Effects of dehydroepiandrosterone supplement on health-related quality of life in glucocorticoid treated female patients with systemic lupus erythematosus.
The safety of 52 weeks of oral DHEA therapy for postmenopausal women. Panjari M, Davis SR. DHEA therapy for women: effect on sexual function and wellbeing. Hum Reprod Update. Effect of 1-year oral administration of dehydroepiandrosterone to to year-old individuals on muscle function and cross-sectional area: a double-blind placebo-controlled trial.
Double-blind placebo-controlled trial of oral dehydroepiandrosterone in patients with advanced HIV disease. Metabolic and hormonal effects of oral DHEA in premenopausal women with HIV infection: a randomized, prospective, placebo-controlled pilot study. Horm Metab Res. Dehydroepiandrosterone in the treatment of erectile dysfunction: a prospective, double-blind, randomized, placebo-controlled study.
Sawalha AH, Kovats S. Dehydroepiandrosterone in systemic lupus erythematosus. Curr Rheumatol Rep. Schifitto G. Autonomic performance and dehydroepiandrosterone sulfate levels in HIV-1 infected individuals; relationship to TH1 and TH2 cytokine profile. Arch Neurol. Stoll BA. Review: Dietary supplements of deydroepiandrosterone in relation to breast cancer risk. Eur J Clin Nut. The andropause and memory loss: is there a link between androgen decline and dementia in the aging male?
Asian J Androl. Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging. Brain Res Rev. Dehydroepiandrosterone for the treatment of systemic lupus erythematosus. One study in Urology looked at men with ED and found that those who took DHEA daily for six months had an improved ability to achieve or maintain an erection; however, it did not affect their testosterone levels Reiter, Some small studies suggest that DHEA may help reduce abdominal fat and insulin resistance, factors linked to type 2 diabetes Villareal, However, other studies do not show that DHEA is effective for weight loss and treating obesity Jedrzejuk, More research is required to identify an association between DHEA and obesity or weight loss.
For the few immune diseases for which DHEA has been tested, like Sjogren syndrome, the results have not been promising Hartkamp, Additional research is needed to determine the safety of DHEA supplementation. According to the NIH, DHEA is probably safe to take at regular doses 50 mg per day for less than two years; it is possibly unsafe if taken at higher doses or for more extended periods. Most side effects of DHEA supplements are mild and can include acne and an upset stomach.
Some men may note breast pain or enlargement NIH, DHEA supplements may be harmful to people with health conditions such as depression, bipolar disorder, diabetes, heart disease, liver disease, and prostate cancer. They also carry a list of potential interactions with various medications. Seek medical advice regarding any possible drug interactions with medicines that you may be taking, like antidepressants, diabetes medications, blood thinners, testosterone supplements , and others NIH, Although the DHEA dosage varies by the specific need and formula, the typical daily dose is approximately 50— mg by mouth NIH, DHEA supplements are potentially unsafe if you use them for longer than two years or take more than mg per day.
The vaginal dryness or inflammation of the vaginal walls can lead to pain during sexual intercourse and urinary symptoms. The FDA approved Prasterone brand name Intrarosa inserts in , which can reduce pain during sex in postmenopausal women.
Additionally, both muscle and bone become more dense when exposed to DHEA. DHEA is believed to play an important role in mood regulation, which helps to explain why people with low DHEA so often experience depressive symptoms and fatigue.
Restoring your DHEA to levels may therefore have a significant impact on your emotional well-being and energy levels and give you the critical support necessary to feel like yourself again. In fact, researchers have found that DHEA can improve feelings of general well-being and may even be used to treat major and minor depression. A growing body of evidence also suggests that DHEA treatment can help improve sexual desire and function.
One study found that women diagnosed with hypoactive sexual desire disorder experienced a significant increase in sexual desire when treated with DHEA over the course of six weeks. There is some evidence that DHEA can also improve libido and correct erectile dysfunction in men, but more research is needed to establish a relationship. They will begin by testing your hormone levels and thoroughly assessing your health in order to design a treatment plan that will help you achieve your goals.
With the right supports, you can address your physical and emotional symptoms while enhancing overall wellness, helping you feel like yourself again. BodyLogicMD can help you get started with DHEA treatment with expert care from a highly-trained practitioner who specializes in bioidentical hormone replacement therapy and integrative medicine.
The practitioners within the BodyLogicMD network are among the top medical professionals in the country and specially certified to help you address hormonal issues like low DHEA so that you can experience the life you deserve. Get started on a customized treatment plan designed to fit your lifestyle and help you reach optimal wellness — contact a local practitioner to schedule your first appointment or take the BodyLogicMD Hormone Balance Quiz today.
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